genotoxicity相关论文
More efficient induction of genotoxicity by high-LET Fe-particle radiation than low-LET X-ray radiat
Objective:Tounderstanddifferentialeffectsoninductionofgenotoxicityandgenomicinstability(GI)byhigh-LETparticleradiationan......
Colorectal cancer (CRC) is the third most common and the second most fatal cancer. In recent years, more attention has b......
Nanotoxicology has become the subject of intense research for more than two decades.Thousands of articles have been publ......
Objective:To assess the genotoxicity and embryotoxicity of bicyclol methyl ether (BME),the main impurity in bicyclol.Met......
Objective:To understand the effects of MOM artificial joint prosthesis material impacted on the human body the Wing Soma......
Objective:This study was designed to investage the mechanism of toxic effect of the cobalt nanoparticles(Co-NPs) and cob......
Objective: This study was to assess the potential genetic toxicity in surrounding tissue of joint and distant organs in ......
Historically, studies using laboratory animals such as the in vivo bone marrow MN assay and the in vivo unscheduled DNA ......
Although mesoporous silica nanoparticles(MS)is widely used in food products,cosmetics and nanomedicine as vector for dru......
Co-exposure to amorphous silica nanoparticles and benzo[a]pyrene at low level in human bronchial epi
Both ultrafine particles (UFP) and polycyclic aromatic hydrocarbons (PAHs) are widely presented in the environment,incre......
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DEHP and Its Metabolite MEHP Cause Genotoxicity and Mutagenesis in Mammalian Chinese Hamster Ovary C
DEHP, Di-(2-ethylhexyl) phthalate, the most common phthalate plasticizer used in the production ofpolyvinyl chloride (PV......
In silico and in vitro genotoxicity evaluation of descarboxyl levofloxacin, an impurity in levofloxa
OBJECTIVE To evaluate the genotoxicity of Descarboxyl Levofloxacin by In silico and In vitro methods.METHODS Assessment ......
Quantitative Genotoxicity Assessment and Clustering of Disinfection By-products by Using Recombinant
Genotoxicity testing is performed for the detection of DNA damage,or to assay for the formation of a DNA adduct and chro......
A new genotoxicity evaluation method based on the γ-H2AX using chromatography-triple quadrupole tand
Genotoxic substances are substances that can directly or indirectly damage cellular DNA,cause gene mutation or mutugenes......
In this study A549 cell viability, extracellular activities of lactate dehydrogenase (LDH), tumor necrosis factor (TNF)-......
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Genotoxicity assays were conducted on male Sprague Dawley rats treated with 5-? uorouracil (5-FU), melamine and 4-ni......
Genotoxicity of 1-methylpyrene and 1-hydroxymethylpyrene in Chinese hamster V79-derived cells expres
1-Methylpyrene is a widespread pollutant that is carcinogenic in animals following metabolic activation.Previous stu......
By detecting the influence of six main ingredients of PM2.5 mineral dusts on the A549 cell morphology, proliferation inh......
GFP tracking transcriptional activity endogenous p53: vector construction and application in genotox
To establish a sensitive.and specific system for genotoxicity detection in vivo. Methods: Endogenous p53 tracer vector p......
目的 检测分析钱塘江水环境中有机物污染及遗传毒性.方法 对钱塘江水系中衢州樟潭、淳安街口、建德将军岩、严东关,桐庐、富阳、萧......
砷是一种广泛存在于自然环境中的化学污染物，国际癌症研究机构（IARC）已经明确砷及其化合物是人类致癌物，地方性砷中毒也成为了严重危害......
Evaluation of naproxen-induced oxidative stress, hepatotoxicity and in-vivo genotoxicity in male Wis
Naproxen (NP), a nonsteroidal anti-inflammatory drug (NSAID), is used for the treatment of common pain, inflammation and......
Cytotoxicity and genotoxicity assessment of Euphorbia hirta in MCF-7 cell line model using comet ass
Objective:To evaluate the cytotoxicity and genotoxicity activity of Euphorbia hirta (E. hirta) in MCF-7 cell line model ......
Effect ofBuchanania lanzan Spreng. bark extract on cyclophosphamide induced genotoxicity and oxidati
Objective:To elucidate the effect of ethanolic extract ofBuchanania lanzan Spreng. (B. lanan) bark against cyclophospham......
Assessment of genotoxicity and cytotoxicity of standardized aqueous extract from leaves ofErythroxyl
Objective:To investigate the cytotoxicity and the genotoxicity of standardized aqueous of dry leaves ofErythroxylum cune......
Objective:To explore the genotoxic potential and histopathological changes induced in liver,kidney,testis,brain and hear......
目的 评价发酵法L-丙氨酸的急性毒性与遗传毒性.方法 选择健康成年清洁级ICR雌雄小鼠各10只,以最大耐受量(MTD,15.0 g/kg)经口灌胃......
目的 研究饮用水中2,6-二氯-1,4-苯醌(2,6-DCBQ)对小鼠的急性毒性和遗传毒性作用.方法 选择健康6～8周龄SPF级昆明小鼠进行试验.将50......
Acute andchronic cytotoxicity and genotoxicity induced by2,6-dichloro-1,4-benzoquinone in NIH3T3cell
Objective:This study aimed to evaluate the acute and chronic cytotoxicity and genotoxicity of 2,6-dichloro-1,4-benzoquin......
本文通过对荣华二采区10...
Double-endpoint Genotoxicity Quantification and PAHs Characterization of Drinking Water Source along
The etiology for the high tumor mortality in heavy polluted Yinghe river basin is still unclear and polycyclic aromatic ......
研究黄蜀葵花提取物金丝桃苷的急性毒性和遗传毒性,对其安全性进行评价.急性毒性试验中,选用健康BALB/c小鼠40只,雌雄各半,灌胃给......
为了探究辅酶Q10如何调节免疫功能,采用了低、中、高三种剂量辅酶Q10对模型小鼠进行药物处理,检测其是否具有毒性或遗传毒性.采用......
欧盟对化妆品指令的第七次修改中规定,全面禁止动物实验用于化妆品的遗传毒性评价,但目前现有的体外遗传毒性试验存在较高的假阳性......
本文主要研究了新药研发中体外遗传毒性试验中风险故障树的构建以及风险因素权重分析。针对体外遗传毒性试验风险,构建了一个体外......
目的:探讨链状酰胺类化合物B07是否存在遗传毒性.方法:通过Ames试验、中国仓鼠肺成纤维细胞(CHL)染色体畸变试验和大鼠骨髓嗜多染......
Arsenic (As),one of the most harmful toxicant at the global level,severely affects plant metabolism when taken up.Intere......
,Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicit
Virus-based vectors are widely used in hematopoietic stem cell (HSC) gene therapy,and have the ability to integrate perm......
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Characterisation of acute toxicity, genotoxicity and oxidative stress posed by textile effluent on z
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Cytotoxicity and genotoxicity evaluation of urban surface waters using freshwater luminescent bacter
The freshwater luminescent bacteria Vibrio-qinghaiensis sp.-Q67 test and the Vicia faba root tip test associated with so......
Toxicity-based assessment of the treatment performance of wastewater treatment and reclamation proce
The reclamation and reuse of wastewater is one of the possible ways to relieve the serious fresh water resource crisis i......
随着水源水微污染问题的日益突出和水质标准的不断提高,传统的水处理技术面临严峻挑战.膜处理是目前饮用水深度处理的有效手段.选......
目的对大鼠Pig-a基因突变试验方法进行优化,并初步探讨阳性诱变剂N-乙基-N-亚硝基脲(ENU)在该实验中的时-效关系和量-效关系。方法......
Genotoxicity evaluation of drinking water sources in human peripheral blood lymphocytes using the co
The potential harm of organic pollutants in drinking water to human health is widely focused on in the world; more and m......
In vitro cytotoxicity of CdSe/ZnS quantum dots with different surface coatings to human keratinocyte
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Inorganic arsenic induces a variety of toxicities including cancer. The mode of action for cancer and non-cancer effects......
